A PAN-TUMOR-SIRNA APTAMER CHIMERA TO BLOCK NONSENSE-MEDIATED MRNA DECAY INFLAMES AND SUPPRESSES TUMOR PROGRESSION

A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression

Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments.There is an unmet need to develop a feasible clinical therapeutic platform to increase the rate of response to ICB.Here we Skin Lotion use a previously desc

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Offloading Mechanisms Based on Reinforcement Learning and Deep Learning Algorithms in the Fog Computing Environment

Fog computing has emerged as a computing paradigm for resource-restricted Internet of things (IoT) devices to support time-sensitive and computationally intensive applications.Offloading can be utilized to transfer resource-intensive tasks from resource-limited end devices to a resource-rich fog or cloud layer to reduce end-to-end latency and enhan

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Transcriptional and biochemical profiling of defense enzymes in Citrus sinensis during salicylic acid and cinnamon mediated suppression of green and blue mold

Green and blue mold of citrus are threatening diseases that continuously inflict economic post-harvest loss.The suppressive effect of salicylic (SA) and Cinnamomum verum (CV) on green and blue mold of sweet oranges was investigated in this study.Among five tested plant extracts methanolic extract of Cinnamon caused the highest colony growth inhibit

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